cforyourself vitamin d

Vitamin D belongs to the family of fat-soluble vitamins, which include vitamins A, D, E and K. These vitamins are absorbed well with fat and are stored in the liver and fatty tissues. Vitamin D is an important nutrient that aids a variety of functions in people of all ages, including bone health and metabolism. The concurrent presence of fat in the gut enhances vitamin D absorption, but some vitamin D is absorbed even without dietary fat. [, Rockwell M, Kraak V, Hulver M, Epling J. Both vitamins D2 and D3 raise serum 25(OH)D levels, and they seem to have equivalent ability to cure rickets [4]. [, Crockett SD, Barry EL, Mott LA, Ahnen DJ, Robertson DJ, Anderson JC, et al. Public Health Nutrition 2020;23:1153-64. Overall, the risk of CVD events was 10% lower for each 25 nmol/L (10 ng/mL) increase in serum 25(OH)D. Another large observational study that followed 247,574 adults from Denmark for 07 years found that levels of 25(OH)D that were low (about 12.5 nmol/L [5 ng/mL]) and high (about 125 nmol/L [50 ng/mL]) were associated with a greater risk of mortality from CVD, stroke, and acute myocardial infarction [121]. Vitamin D supplementation reduced cancer mortality rates by 13%, and most of the benefit occurred with daily supplementation. Again, the pattern was similar for the risk of inadequacy. Vitamin D supplementation has no effect on insulin sensitivity or secretion in vitamin D-deficient, overweight or obese adults: A randomized placebo-controlled trial. The USPSTF also reviewed the seven published studies on the effects of vitamin D supplementation (two of them also included calcium supplementation) on the risk of falls in community-dwelling adults aged 65 years or older who did not have osteoporosis or vitamin D deficiency. [. Because vitamin D is fat soluble, its absorption depends on the guts ability to absorb dietary fat [4]. In fact, Black Americans might have a greater risk than White Americans of falls and fractures with daily vitamin D intakes of 50 mcg (2,000 IU) or more [14]. Serum vitamin D and risk of breast cancer within five years. [, Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, et al. I produce this site out of my passionate desire to inform as many people as possible about the nature of our body's need for the proper nutrients in adequate amounts. This damage hinders or blocks messages between the brain and body, leading to clinical features, such as vision loss, motor weakness, spasticity, ataxia, tremor, sensory loss, and cognitive impairment [136,137]. Although UVB exposure can produce vitamin D in infants, the American Academy of Pediatrics (AAP) advises parents to keep infants younger than 6 months out of direct sunlight, dress them in protective clothing and hats, and apply sunscreen on small areas of exposed skin when sun exposure is unavoidable [59]. British Journal of Cancer 2014;111:976-80. Calcium and vitamin D supplementation and increased risk of serrated polyps: Results from a randomised clinical trial. For a reader-friendly overview of Vitamin D, see our consumer fact sheet on Vitamin D. For information on vitamin D and COVID-19, see Dietary Supplements in the Time of COVID-19. Another study that compared 200 male smokers in Finland with pancreatic cancer to 400 matched controls found that participants in the highest quintile of 25(OH)D levels (more than 65.5 nmol/L [26.2 ng/mL]) had a threefold greater risk of developing pancreatic cancer over 16.7 years than those in the lowest quintile (less than 32 nmol/L [12.8 ng/mL]) [106]. Corticosteroid medications, such as prednisone (Deltasone, Rayos, and Sterapred), are often prescribed to reduce inflammation. Vitamin D is required to maintain serum calcium concentration within the normal physiologic range for musculoskeletal health. Nutrients 2018; 10, 375; doi:10.3390/nu10030375 [, Mousa A, Naderpoor N, Teede H, Scragg R, de Courten, B. Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. These participants were randomized to take 25 mcg (1,000 IU) vitamin D3, 1,200 mg calcium, both supplements, or a placebo daily for 35 years, followed by an additional 35 years of observation after participants stopped the treatment. [, Crowe M, Wollner L, Griffiths RA. [, Mheid IA, Quyyumi AA. Vitamin C in high doses (up to 100 grams/day or more IV) has been shown to be very effective in the treatment of cancer. Vitamin D: Nutrient-densea Food and Beverage Sources, Amounts of Vitamin D and Energy per Standard Portion a All foods listed are assumed to be in nutrient-dense forms; lean or low-fat and prepared with minimal added sugars, saturated fat, or sodium. Ready-to-eat breakfast cereals often contain added vitamin D, as do some brands of orange juice, yogurt, margarine, and other food products. Office of Dietary Supplements, National Institutes of Health. Vitamin D might be involved in the pathophysiology of type 2 diabetes through its effects on glucose metabolism and insulin signaling as well as its ability to reduce inflammation and improve pancreatic beta-cell function [1443,145]. In 1935, the chemical structure of vitamin D 3 was defined and shown to result from the ultraviolet irradiation . J Clin Endocrinol Metab 2011;96:3838-45. Most participants (78%) had adequate serum levels of vitamin D at baseline (at least 50 nmol/L [20 ng/mL]). Participants were randomized to take either 30 mcg (1,200 IU)/day vitamin D3 or a placebo for 1 year. Ann Intern Med 2014;160:810-1. [. [, Schenk JM, Till CA, Tangen CM, Goodman PJ, Song X, Torkko KC, et al. The following groups are among those most likely to have inadequate vitamin D status. All adults should consume recommended amounts of vitamin D and calcium from foods and supplements if needed. Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause adverse health effects. alert icon. [, Chalcraft JR, Cardinal LM, Wechsler PJ, Hollis BW, Gerow KG, Alexander BM, et al. [, Gotfredsen A, Westergren Hendel H, Andersen T. Influence of orlistat on bone turnover and body composition. Observational studies support an association between higher serum 25(OH)D levels and a lower risk of CVD incidence and mortality. Those of African American ancestry, for example, have lower rates of bone fracture and osteoporosis than do Whites (see the section below on bone health and osteoporosis). karen rietz baldwin; hidden valley high school yearbook. Report / Delete 3 Reply andreaalvarez kristine98132 Posted 4 years ago Vitamin D helps you absorb calcium and phosphate from food. [, Malihi Z, Wu Z, Stewart AW, Lawes CMM, Scragg R. Hypercalcemia, hypercalciuria, and kidney stones in long-term studies of vitamin D supplementation: A systematic review and meta-analysis. Vitamin D is a pro-hormone. Among postmenopausal women and older men, many clinical trials have shown that supplements of both vitamin D and calcium result in small increases in bone mineral density throughout the skeleton [1,74]. One might expect a large proportion of the U.S. population to have vitamin D inadequacy on the basis of vitamin D intakes from foods, beverages, and even dietary supplements. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. [, Simon AE, Ahrens KA. [, Manson JE, Cook NR, Lee I-M, Christen W, Bassuk S, Mora S, et al. [, Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Krstic G, Wetterslev J, Gluud C. Vitamin D supplementation for prevention of cancer in adults. Another recent systematic review also found that vitamin D and calcium supplements had no beneficial effects on fractures, falls, or bone mineral density [79,80]. Scientific Reports 2020;10:7736. Levels of 1,25(OH)2D do not typically decrease until vitamin D deficiency is severe [2]. Not all research indicates that vitamin D supplementation optimizes testosterone levels, though. The data on supplemental vitamin D and cholesterol levels are mixed, as shown in one meta-analysis of 41 clinical trials in a total of 3,434 participants (mean age 55 years). J Am Coll Cardiol 2017;70:89-100. Effects of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. International Journal of Epidemiology 2019;48:1416-24. Older women and men should consult their health care providers about their needs for both nutrients as part of an overall plan to maintain bone health and to prevent or treat osteoporosis. Nutrients 2019;11,2295; doi:10.3390/nu11102295. products like plain whole cow's milk (for children 12 months and older), yogurt, cereals, and some 100% juices. Neither aging nor obesity alters vitamin D absorption from the gut [4]. Toxicity of vitamin D leads to hypercalcemia and imbalance in the regulation of bone metabolism; the resultant hypercalcemia leads to clinical manifestations and symptoms of toxicity. Am J Clin Nutr 2004;80:1710S-6S. However, the results did show an increased risk of pancreatic cancer with 25(OH)D levels of 100 nmol/L (40 ng/mL) or above [107]. Experts have reached no firm consensus on whether vitamin D can help prevent MS given the lack of clinical trial evidence [142]. Twitter. [, Chakhtoura MT, Nakhoul N, Akl EA, Mantzoros CS, El Hajj Guleihan GA. Vitamin D supplementation and risk of toxicity in pediatrics: A review of current literature. At baseline, participants had an adequate mean serum 25(OH)D level of 60 nmol/L (24 ng/mL). Very high levels of vitamin D in your blood (greater than 375 nmol/L or 150 ng/mL) can cause nausea, vomiting, muscle weakness, confusion, pain, loss of appetite, dehydration, excessive urination and thirst, and kidney stones. Breastfed infants [, Creo AL, Thacher TD, Pettifor JM, Strand MA, Ficsher PR. Older adults Cholecalciferol or 25-hydroxycholecalciferol supplementation does not affect muscle strength and physical performance in prefrail and frail older adults. PMID: 31504098 [, Okereke OI, Reynolds III CF, Mischoulon D, Chang G, Vyas CM, Cook NR, et al. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. CMAJ 2019;191:E390-4. The British Journal of Psychiatry 2013;202:100-7. 25-hydroxyvitamin D levels and risk of ischemic heart disease, myocardial infarction, and early death: Population-based study and meta-analyses of 18 and 17 studies. Rates of breast, prostate, and colorectal cancer did not differ significantly between the vitamin D and placebo groups. The Dietary Guidelines for Americans describes a healthy dietary pattern as one that: This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. Best liquid: Designs for Health Liposomal D Supreme. US Preventive Services Task Force recommendation statement. June 2014. [, Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M. Cardiovascular disease and vitamin D supplementation: Trial analysis, systematic review, and meta-analysis. [, Auguste BL, Avila-Casado C, Bargman JM. The Endocrine Society states, for example, that to maintain serum 25(OH)D levels above 75 nmol/L (30 ng/mL), adults might need at least 37.5 to 50 mcg (1,5002,000 IU)/day of supplemental vitamin D, and children and adolescents might need at least 25 mcg (1,000 IU)/day [11]. Other meta-analyses of prospective studies have found associations between lower vitamin D status measured by serum 25(OH)D levels or vitamin D intakes and an increased risk of ischemic stroke, ischemic heart disease, myocardial infarction, and early death [122,123]. High serum cholesterol levels and hypertension are two of the main risk factors for CVD. [, de Koning EJ, Lips P, Penninx BWJH, Elders PJM, Heijboer AC, den Heijer M, et al. [, Yin L, Ordonez-Mena JM, Chen T, Schottker B, Arndt V, Brenner H. Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis. A few examples are provided below. A 2018 Cochrane review analyzed 12 such trials that had a total of 933 participants with MS; the reviewers judged all of these trials to be of low quality [137]. Cancer Epidemiol Biomarkers Prev 2014;23:1494-504. Assessing the vitamin D status of the US population. Total vitamin D intakes were three times higher with supplement use than with diet alone; the mean intake from foods and beverages alone for individuals aged 2 and older was 4.8 mcg (192 IU) but increased to 19.9 mcg (796 IU) when dietary supplements were included. However, a post hoc analysis showed a 62% lower incidence of diabetes among participants with low baseline serum 25(OH)D levels (less than 30 nmol/L [12 ng/mL]) who took the vitamin D supplement than among those who took the placebo [145,150]. N Engl J Med 2019;381:520-30. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Because vitamin D increases calcium absorption in the gastrointestinal tract, vitamin D toxicity results in marked hypercalcemia (total calcium greater than 11.1 mg/dL, beyond the normal range of 8.4 to 10.2 mg/dL), hypercalciuria, and high serum 25(OH)D levels (typically greater than 375 nmol/l [150 ng/mL]) [155]. Show Out of Stock Items. [, Yetley EA. [, Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Pediatrics 2008;122:1142-52. [, Mallard SR, Howe AS, Houghton LA. Over time, bone density can decline, and osteoporosis can eventually develop [71]. Vitamin D status in gastrointestinal and liver disease. OVERVIEW; PRIMER; IN THE NEWS [, Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, et al. In addition, high intakes of vitamin D, especially from supplements, might reduce the potency of atorvastatin (Lipitor), lovastatin (Altoprev and Mevacor), and simvastatin (FloLipid and Zocor), because these statins and vitamin D appear to compete for the same metabolizing enzyme [167-170]. Nutrients 2018, 10, 59; doi:10.3390/nu10010059. Vitamin D supplements and prevention of cancer and cardiovascular disease. Although 25(OH)D functions as a biomarker of exposure, the extent to which 25(OH)D levels also serve as a biomarker of effect on the body (i.e., relating to health status or outcomes) is not clear [1,3]. Nutrients 2018; 10, 277;doi:10.3390/nu10030277. This video is all about new range of the moms co vitamin c range products I have reviewed and explained the benefits I hope you all wil. Les sites web associs 'MCS' : recherchez avec meeZoom les sites proposs et classs par les autres internautes. Cforyourself is dedicated to the dissemination of information about vitamin C . [, Taylor CL, Patterson KY, Roseland JM, Wise SA, Merkel JM, Pehrsson PR, Yetley EA. Elsevier, 2018. The emerging issue of 25-hydroxyvitamin D in foods. Nutr Rev 2019;77:890-902. People with obesity might need greater intakes of vitamin D to achieve 25(OH)D levels similar to those of people with normal weight [1,64,65]. Am J Med 2015;128:1167-70. [, Robien K, Oppeneer SJ, Kelly JA, Hamilton-Reeves JM. [, Scragg R, Stewart AW, Waayer D, Lawes CMM, Toop L, Sluyter J, et al. People can develop vitamin D deficiency when usual intakes are lower over time than recommended levels, exposure to sunlight is limited, the kidneys cannot convert 25(OH)D to its active form, or absorption of vitamin D from the digestive tract is inadequate. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Am J Clin Nutr 2017;106:481-90. [. [, Kahwati LC, Weber RP, Pan H, Gourlay M, LeBlanc E, Coker-Schwimmer M, Viswanathan M. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: Evidence report and systematic review for the US Preventive Services Task Force. The factors that affect UV radiation exposure, individual responsiveness, and uncertainties about the amount of sun exposure needed to maintain adequate vitamin D levels make it difficult to provide guidelines on how much sun exposure is required for sufficient vitamin D synthesis [15,28]. J Clin Endocrinol Metab 2011;96:1911-30. As a result, a finding can be falsely low or falsely high, depending on the assay used and the laboratory. Similarly, in a review of data from nearly 250 studies published between 2009 and 2013, the Agency for Healthcare Research and Quality concluded that no relationship could be firmly established between vitamin D and health outcomes other than bone health [69]. US Preventive Services Task Force recommendation statement. doi: 10.1002/14651858.CD007469.pub2. The second trial included 155 adults aged 6080 years who had clinically relevant depressive symptoms, no major depressive disorder, and serum 25(OH)D levels less than 50 to 70 nmol/L (20 to 28 ng/mL) depending on the season; in addition, they were not taking antidepressants [133,134]. Both forms are well absorbed in the small intestine. Calcium plus vitamin D supplementation and the risk of breast cancer. Elsevier, 2018. The Women's Health Initiative clinical trial randomized 36,282 postmenopausal women to receive 400 IU vitamin D3 plus 1,000 mg calcium daily or a placebo for a mean of 7 years [98]. Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by vitamin D. Many tissues have vitamin D receptors, and some convert 25(OH)D to 1,25(OH)2D. [, Shea MK, Fielding RA, Dawson-Hughes B. More recently, a 2022 ancillary study of the Vitamin D and Omega-3 Trial (VITAL; described in the Cancer section below) investigated whether supplemental vitamin D3 (50 mcg [2,000 IU]/day) would lower the risk of fractures in 25,871 generally healthy men aged 50 years and older and women aged 55 years and older over a median follow-up of 5.3 years [82]. Several studies have examined whether levels of 25(OH)D in men with prostate cancer are associated with a lower risk of death from the disease or from any cause. Below are brief descriptions of studies of vitamin D and its association with, or effect on, breast, colorectal, lung, pancreatic, and prostate cancers. A meta-analysis of 3 randomized controlled trials in 1,273 men with prostate cancer found no significant differences in total mortality rates between those receiving vitamin D supplementation (from 10 mcg [400 IU]/day for 28 days to 45 mcg [1,800 IU] given in three doses total at 2-week intervals) and those receiving a placebo [116]. Uneven skin tone, dryness & texture may feel rough to the touch and give your skin a dull appearance..Adding Vitamin C in your skincare routine is must of su. We encourage you to talk to your health care providers (doctor, registered dietitian, pharmacist, etc.) Am J Clin Nutr 2004;80:1697S-705S. Questions about vitamin D for primary care practice: Input from an NIH conference. The FNB committee that established DRIs for vitamin D found that the evidence was inadequate or too contradictory to conclude that the vitamin had any effect on a long list of potential health outcomes (e.g., on resistance to chronic diseases or functional measures), except for measures related to bone health. In a subsequent investigation for 4.9 years after the study's end, women who had taken the vitamin D and calcium supplements (many of whom continued to take them) still had the same colorectal cancer risk as those who received placebo [100]. JAMA Cardiol 2017;2:608-16. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. In a subsequent investigation for 4.9 years after the study's end, women who had taken the vitamin D and calcium supplements (many of whom continued to take them) had an 18% lower risk of in situ (noninvasive) breast cancer [100]. It helps the bones absorb calcium, supports the immune system and may aid strength gain and fat loss. Intestinal absorption of vitamin D: A systematic review. In addition, inadequate vitamin D levels can adversely affect muscle strength and lead to muscle weakness and pain (myopathy) [1]. Am J Clin Nutr 2019;110:1043-4. However, frequent use of tanning beds, which provide artificial UV radiation, can lead to 25(OH)D levels well above 375500 nmol/L (150200 ng/mL) [158-160]. DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. [, Song Z-y, Yao Q, Zhuo Z, Ma Z, Chen G. Circulating vitamin D level and mortality in prostate cancer patients: A dose-response meta-analysis. Adv Nutr 2012;3:353-61. Federal agencies and national organizations advise taking photoprotective measures to reduce the risk of skin cancer, including using sunscreen with a sun protection factor (SPF) of 15 or higher, whenever people are exposed to the sun [28,30]. Consumption of human milk alone does not ordinarily enable infants to meet vitamin D requirements, because it provides less than 0.6 to 2.0 mcg/L (25 to 78 IU/L) [1,56,57]. In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients (e.g., during specific life stages such as pregnancy).". [, Ekwaru JP, Zwicker JD, Holick MF, Giovannucci E, Veugelers PJ. Journal of Nutrition Science 2018;7:1-7. [. Vitamin D- fortified. However, higher serum 25(OH)D levels (at a cut point of 75 nmol/L [30 ng/mL]) were linked to a modestly higher risk of slow-growth prostate cancer and a more substantial lower risk of aggressive disease. Vitamin D and calcium: A systematic review of health outcomes. [, Nair-Shalliker V, Bang A, Egger S, Clements M, Gardiner RA, Kricker A, et al. A one-year trial to assess the value of orlistat in the management of obesity. Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals. For example, a meta-analysis of 9 trials with a total of 4,923 adult participants diagnosed with depression or depressive symptoms found no significant reduction in symptoms after supplementation with vitamin D [131]. In addition, most steps in the metabolism and actions of vitamins D2 and D3 are identical. Older adults are at increased risk of developing vitamin D insufficiency, partly because the skin's ability to synthesize vitamin D declines with age [1,61]. Vitamin D deficiency is associated with vascular dysfunction, arterial stiffening, left ventricular hypertrophy, and hyperlipidemia [119]. In a trial in Norway, 511 men and women aged 2580 years (mean age 62 years) with prediabetes received 500 mcg (20,000 IU) vitamin D3 or a placebo each week for 5 years [149]. Some observational studies support an inverse association between 25(OH)D levels and breast cancer risk and mortality, but others do not [94-97]. The analysis of 20152016 data also showed that 28% of all individuals aged 2 years and older in the United States took a dietary supplement containing vitamin D [39]. Observational studies indicate that greater body weights are associated with lower vitamin D status, and individuals with obesity frequently have marginal or deficient circulating 25(OH)D levels [151]. The federal government's 2020-2025 Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. Rockville, MD: Agency for Healthcare Research and Quality, 2009. Happy #SelfCareDay with our favourite Vitamin C Skincare Range that comes with Natural Vitamin C Face Wash Natural Vitamin C Face Serum Natural Vi. Obtaining sufficient vitamin D from natural (nonfortified) food sources alone is difficult. Paediatr Int Child Health 2017;37:84-98. Washington DC: Wiley-Blackwell, 2012. [, Helzlsouer KJ for the VDPP Steering Committee. In contrast to observational studies, clinical trials provide little support for the benefits of vitamin D supplementation for glucose homeostasis. The impact of this form on vitamin D status is an emerging area of research. [, Anglin RES, Samaan Z, Walter SD, McDonald SD. It may even help prevent cancer and protect against. Research to date provides mixed evidence on whether levels of 25(OH)D are associated with the development of prostate cancer. In extreme cases, vitamin D toxicity causes renal failure, calcification of soft tissues throughout the body (including in coronary vessels and heart valves), cardiac arrhythmias, and even death. A systematic review and meta-analysis of 15 weight-loss intervention studies that used caloric restriction, exercise, or both, but not necessarily vitamin D supplementation or other treatments, found that people who lost weight had significantly greater increases in serum 25(OH)D levels than those who maintained their weight [152]. Pancreatic cancer National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center. One systematic review and meta-analysis of 11 randomized, controlled trials published through 2018 of vitamin D supplementation alone (1020 mcg [400800 IU]/day or more at least every week or as rarely as once a year) for 9 months to 5 years found that the supplements provided no protection from fractures in 34,243 older adults [81]. Of cancer and protect against SR, Howe as, Houghton LA acute ischemic heart disease [ 4 ] JD... Pr, Yetley EA older adults Cholecalciferol or 25-hydroxycholecalciferol supplementation does not affect muscle strength physical. Torkko KC, et al ) food sources alone is difficult, Westergren Hendel H, Andersen Influence. Until vitamin D supplementation optimizes testosterone levels, though and a lower risk of CVD and! Nr, Lee I-M, Christen W, Bassuk S, Mora S, et al Sempos CT, AC! Nair-Shalliker V, Bang a, Westergren Hendel H, Andersen T. Influence of orlistat in the gut vitamin... 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